REM in a scientific comparison
Published on 15 February 2024, the HARMONI analysis by Paul Doghramji, Janet Fason and Peter Hurwitz examines SuperPatch REM. Of the adults with sleep complaints, 113 used REM and 20 a similar-looking patch without VTT. Self-reports were collected at baseline and after 7 and 14 days. Participants were blinded; allocation was not randomised. [1]
Positive changes after 14 days
The REM group reported shorter sleep onset, longer sleep and lower PSQI and ISI scores. Lower questionnaire scores indicate fewer reported sleep problems. The table shows averages within the REM group, not placebo-adjusted effects. The authors report no corresponding improvements in the small control group. [1]
| Measure | Baseline | After 14 days |
|---|---|---|
| Sleep onset (minutes) | 69.1 | 36.6 |
| Sleep duration (hours) | 5.25 | 6.51 |
| Global PSQI score | 12.5 | 5.5 |
| ISI score | 18.7 | 8.1 |
What the findings tell us
The findings offer promising indications of REM's potential. The short follow-up, unequal groups and subjective reports limit their strength. Sleep stages were not objectively measured here. Srysty Holding Co. funded the study, administered by Clarity Science. Investigators were compensated; co-author Hurwitz is Clarity Science's president. No serious adverse events were reported, but the REM group had five side-effect reports. [1]
Understanding HARMONI 2023 and 2024
The article dated 29 March 2023 initially reports on 113 REM users without an analysed control group. The 2024 article adds a control comparison. Both give the same key REM averages; we treat them as related HARMONI reports rather than two independent confirmations. [1] [2]
What further research is underway?
As of 13 October 2026: RESTORE (NCT06505005) covers FREEDOM and REM, is registered as a randomised crossover study and reports completion on 1 August 2026. Its 150 participants are the total across both areas, not a confirmed REM sample. No results are posted in the registry; its linked FREEDOM publication is not a REM result. Another REM feasibility study, NCT07785960, examines sleep after night shifts in NHS doctors: non-randomised, double-blind, with 20 participants planned, wearables and questionnaires. Status: enrolling by invitation; no registry results posted either. [3] [4]